AI Safety

Nullius in Verba

Company's protocol preserves every synapse at room temperature, winning prizes from Brain Preservation Foundation.

Deep Dive

Nectome, a company founded by Aurelia, has achieved a major breakthrough in brain preservation technology with independent verification from two prominent organizations. Their new method for whole-body, whole-brain human end-of-life preservation can maintain every synapse and cell with enough detail that current neuroscience suggests long-term memories are preserved. The protocol works at room temperature for traditional funerals and remains stable for hundreds of years when cooled. This represents the culmination of nearly a decade of development across two phases: first achieving idealized laboratory preservation (2015-2018), then adapting the technique to real-world human preservation constraints (2018-2025).

The Brain Preservation Foundation awarded Nectome both small- and large-mammal prizes after Ken Hayworth personally supervised and verified preservation of rabbit and pig brains using electron microscopy. The Survival and Flourishing Fund later invested after Andrew Critch witnessed a rat preservation demonstration mimicking human conditions, with samples analyzed by UC Berkeley and University of Chicago researchers. Nectome's aldehyde-stabilized cryopreservation technique has been published in Cryobiology, and their real-world protocol has been submitted as a preprint titled 'Ultrastructural preservation of a whole large mammal brain with a protocol compatible with human physician-assisted death.' Both foundations have reviewed and endorsed the company's claims about their preservation quality.

Key Points
  • Aldehyde-stabilized cryopreservation preserves synaptic nanostructure throughout entire brains and bodies
  • Technique works at room temperature for funerals and remains stable for hundreds of years when cooled
  • Independently verified through live demonstrations on multiple species by Brain Preservation Foundation and Survival and Flourishing Fund

Why It Matters

Could enable future revival by preserving memories and identity at cellular level, transforming end-of-life planning and cryonics.