Neuronal electricality founded in murburn-thermodynamic principles: 1. Background and basic theoretical formulation

A new theoretical paper published on arXiv challenges the foundational understanding of how neurons generate electrical signals. Researchers Kelath Murali Manoj and Nagamani Sukumar propose that neuronal electrical activity arises from murburn-thermodynamic principles—a framework based on stochastic redox (electron transfer) processes—rather than the classic ion-gradient model involving H+, Na+, and K+ fluxes across membranes. The authors introduce a novel state variable called Electron Holding Potential (EHP), a dimensionless field related to electron chemical potential, to explain how neurons achieve resting potential, excitability, and waveform generation.

The paper derives a unified reaction-transport-relaxation equation that combines local redox relaxation dynamics with spatial transport driven by thermodynamic gradients. This single framework naturally produces threshold behavior, all-or-none responses, and stable spike waveforms, without relying on ion channels or membrane potentials as primary drivers. The authors argue that their model provides a direct bridge between metabolic/redox state and electrophysiological behavior, accommodating known physiological variability. They plan to present further evidence, simulations, and falsification agendas in a follow-up paper. If validated, this could fundamentally shift neuroscience's approach to understanding brain function, signaling, and neurological disorders.